RNA Details
Disease Name
heart failure
Tissue
heart
RNA Symbol
mir-128-1
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
NA
Target
SIRT1;p53
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets
Year
2021
Function
"Downregulation of miR-128 ameliorates Ang II-provoked cardiac oxidative stress, hypertrophy, fibrosis, apoptosis, and dysfunction in mice, likely through targeting on PIK3R1/Akt/mTORC1 and/or SIRT1/p53 pathways."